Sodium Hydroxide → HCID 86166943, compound

Participants

Reaction Steps

A solution of N-[1-[2-(3,4-dihydro-2H-1-benzopyran-4-yl)ethyl]-4-piperidinyl]acetamide (3.3 g, 10.9 mmol) in 1.2N hydrochloric acid (35 ml) was heated on a steam bath for 16 h. The reaction mixture was cooled and neutralized with 50% sodium hydroxide solution (pH 12). The basic aqueous solution was extracted with ethyl acetate. The organic extracts were washed with distilled water, dried (Na2SO4), filtered and evaporated in vacuo to afford the title compound (2.85 g, 100%) as an oily gum.

Provenance & Evidence