Lawesson's reagent → HCID 19738148, compound

HRID 2255452Notes

Reaction equation

HRID 2255452 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([S:16][C:17]2[CH:18]=[C:19]3[C:24](=[CH:25][CH:26]=2)[N:23]([CH3:27])[C:22](=O)[CH2:21][CH2:20]3)[CH:5]=[C:6]([C:8]2([O:14][CH3:15])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:7]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:38])=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([S:16][C:17]2[CH:18]=[C:19]3[C:24](=[CH:25][CH:26]=2)[N:23]([CH3:27])[C:22](=[S:38])[CH2:21][CH2:20]3)[CH:5]=[C:6]([C:8]2([O:14][CH3:15])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:7]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 19738153HCID 19738153, compound

Product 1

HCID 19738148HCID 19738148, compoundYield 85%

Procedure

Using the procedure described in Example 1 except that the reaction mixture was heated to reflux for 15 minutes, 4-[5-fluoro-3-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)phenyl]-4-methoxytetrahydropyran was reacted with Lawesson's Reagent to give 4-[5-fluoro-3-(1-methyl-2-thioxo-1,2,3,4-tetrahydroquinolin-6-ylthio)phenyl]-4-methoxytetrahydropyran in 85% yield, m.p. 133.6°-134.2° C.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 15 minutes

Sources & evidence

ORD record
ord-c738a40e6d3f43c8bc7d9b97b76c7e02
Source dataset
uspto-grants-1993_08
Patent number
US05240941

Reaction notes

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