HCID 178517150, compound → HCID 178517348, compound

HRID 2255453Notes

Reaction equation

HRID 2255453 reaction equation
[OH:1][C:2]1[N:3]=[C:4]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=[C:5]2[N:6]=1>CO.[H][H].[Pt]=O>[OH:1][C:2]1[NH:3][C:4]2[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:5]=2[N:6]=1

Participants

5

Reactant 1

HCID 178517150HCID 178517150, compound

Product 1

HCID 178517348HCID 178517348, compoundYield 87.6%

Reagents, catalysts & solvents 3

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

A solution of 2-Hydroxy-cycloheptimidazole (16.0 g) in methanol was stirred vigorously with platinum oxide (0.2 g) in the hydrogen stream. An off-white suspended solution obtained after 16 hrs, was refluxed and filtered. The insoluble material was extracted again with hot methanol (200 ml) and filtered. The combined filtrate was concentrated in reduced pressure. Obtained yellow powder was washed with ethanol (50 ml) and filtered. 14.6 g of the desired compound was obtained. m.p. 272° C./dec.

Workup

  1. customAn off-white suspended solution obtained after 16 hrs
  2. temperaturewas refluxed
  3. filtrationfiltered
  4. extractionThe insoluble material was extracted again with hot methanol (200 ml)
  5. filtrationfiltered
  6. concentrationThe combined filtrate was concentrated in reduced pressure
  7. customObtained yellow powder
  8. washwas washed with ethanol (50 ml)
  9. filtrationfiltered

Sources & evidence

ORD record
ord-04b758d8091345b7bb38866887fd2a6c
Source dataset
uspto-grants-1993_08
Patent number
US05240944

Reaction notes

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