Ethyl orthoformate → HCID 54081328, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-amino-4-(4-cyclohexylphenyl)thiazole hydrochloride (1.0 g) and triethyl orthoformate (5 ml) was stirred at 130° C. for 1 hour. The reaction mixture was concentrated under reduced pressure, and to the remaining crystals was added hexane, followed by filtration. The filtrate was concentrated to give crystals of 4-(4-cyclohexylphenyl)-2-ethoxymethyleneaminothiazole (1.02 g, yield of 95.6 %). Recrystallization from diethyl etherhexane produced yellowish prisms, mp of 84° to 85° C.

Provenance & Evidence