Ethyl vinyl ether → HCID 19737970, compound

Participants

Reaction Conditions

Reaction Steps

The product from Step A (4.2 g, 17.1 mmol) was dissolved in tetrahydrofuran (75 mL) and cooled to 0° C. at which point p-toluenesulfonic acid (163 mg, 0.6 mmol) was added followed by ethylvinyl ether (3.3 mL, 34.3 mmol). This mixture was stirred at 0° C. for 2 h, diluted with cold ethyl acetate (100 mL) and washed with saturated sodium bicarbonate (70 mL) and brine (70 mL). The organic layer was dried (MgSO4) and evaporated to provide 5.2 g of crude product which was used in the next step without further purification.

Provenance & Evidence