Acetic Acid → HCID 9976590, compound

HRID 2255521Notes

Reaction equation

HRID 2255521 reaction equation
Cl.[CH2:2]([N:4]1[CH2:8][CH2:7][CH2:6][C@H:5]1[CH2:9][NH:10][C:11](=[O:22])[C:12]1[C:17]([OH:18])=[CH:16][CH:15]=[C:14]([OH:19])[C:13]=1[O:20][CH3:21])[CH3:3].C(O)(=O)C.[Br:27]Br>O1CCOCC1>[CH2:2]([N:4]1[CH2:8][CH2:7][CH2:6][C@H:5]1[CH2:9][NH:10][C:11](=[O:22])[C:12]1[C:13]([O:20][CH3:21])=[C:14]([OH:19])[CH:15]=[C:16]([Br:27])[C:17]=1[OH:18])[CH3:3]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 24408BromineHCID 67875903HCID 67875903, compound

Product 1

HCID 9976590HCID 9976590, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a mixture of (S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3,6-dihydroxy-2-methoxybenzamide hydrochloride (90 mg, 0.27 mmol), 0.5 ml dioxane and 0.1 ml acetic acid was added a solution of 18 μl bromine (0.35 mmol) in 0.5 ml dioxane. After stirring at room temperature for 1 h the solvent was evaporated.

Workup

  1. customwas evaporated

Sources & evidence

ORD record
ord-36df33c4b1914ed6934edb74f9b0e799
Source dataset
uspto-grants-1993_08
Patent number
US05240957

Reaction notes

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