Ammonia → 2-(4-Methylphenoxy)-2-(2-chlorophenyl)acetamide

HRID 2255565Notes

Reaction equation

HRID 2255565 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([O:13][C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)[C:9](OC)=[O:10].[NH3:21]>CO>[CH3:20][C:17]1[CH:18]=[CH:19][C:14]([O:13][CH:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[C:9]([NH2:21])=[O:10])=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 19385716Methyl 2-(2-chlorophenyl)-2-(4-methylphenoxy)acetate

Product 1

HCID 193855922-(4-Methylphenoxy)-2-(2-chlorophenyl)acetamideYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 0.700 g (2.41 mmol) of methyl 2-(2-chlorophenyl)-2-(4-methylphenoxy)acetate (Example 4, Step B) in 10 mL of methanol, stirred at 0° C. (ice-bath) was added anhydrous NH3 for 45 minutes. The reaction mixture was warmed to room temperature and stirred overnight. The reaction mixture was then concentrated in vacuo and afforded 0.658 g (99%) of title compound.

Workup

  1. concentrationThe reaction mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-8a0c087c34db4429bac9b810426c303e
Source dataset
uspto-grants-1993_08
Patent number
US05240938

Reaction notes

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