HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Methyl 2-(2,6-dichloro-4-hydroxymethylphenoxy)-2-phenylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Benzenemethanol, 3,5-dichloro-4-hydroxy- | HCID 176409 | — |
| Reactant | Methyl 2-(2-bromophenyl)acetate | HCID 8063364 | — |
| Reactant | Acetone potassium carbonate | HCID 86600397 | — |
| Product | Methyl 2-(2,6-dichloro-4-hydroxymethylphenoxy)-2-phenylacetate | HCID 19385731 | 20.4% |
Reaction Steps
Using the K2CO3 /acetone conditions for phenol alkylation described in Step A of Example 30, 0.400 g (2.07 mmol) of the product of Step C was alkylated with 0.522 g (2.28 mmol) of methyl 2-bromophenylacetate to afford 0.144 g (20%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05240938 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-f0c3795688944fcfa574463ff0ad8de9 |
| Source note | uspto-grants-1993_08 |