Phenol → HCID 19385679, compound

HRID 2255618Notes

Reaction equation

HRID 2255618 reaction equation
C([O-])([O-])=O.[K+].[K+].CC(C)=O.C1(O)C=CC=CC=1.[CH3:18][C:19]1([C:25]2[CH:30]=[C:29]([CH3:31])[CH:28]=[CH:27][C:26]=2[OH:32])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.Br[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[CH2:40][C:41]([O:43][CH3:44])=[O:42]>>[CH3:18][C:19]1([C:25]2[CH:30]=[C:29]([CH3:31])[CH:28]=[CH:27][C:26]=2[O:32][CH:40]([C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:34]=2)[C:41]([O:43][CH3:44])=[O:42])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1

Participants

5

Reactant 4

HCID 996PhenolHCID 85304Phenol, 4-methyl-2-(1-methylcyclohexyl)-HCID 8063364Methyl 2-(2-bromophenyl)acetateHCID 86600397Acetone potassium carbonate

Product 1

HCID 19385679HCID 19385679, compoundYield 91.1%

Procedure

Using the K2CO3 /acetone conditions for phenol alkylation described in Step A of Example 30, 0.496 g (2.43 mmol) of 2-(1-methylcyclohex-1-yl)-4-methylphenol was alkylated with 0.834 g (3.64 mmol) of methyl 2-bromophenylacetate to afford 0.780 g (91%) of the title compound.

Sources & evidence

ORD record
ord-643cd08bee344ad99f7fa9ca67ff0362
Source dataset
uspto-grants-1993_08
Patent number
US05240938

Reaction notes

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