反应详情

To a solution of ethyl 2-(1-hydroxyethyl)acrylate (40 g) and pyridine (26.9 ml) in dichloromethane (277 ml) was added dropwise acetyl chloride (23.7 ml) at 0° C. The reaction mixture was stirred for 1 hour and quenched with water (200 ml). The aqueous layer was separated and extracted twice with dichloromethane. The combined organic layers were washed with 1N hydrochloric acid, saturated aqueous sodium hydrogen carbonate water and an aqueous sodium chloride in turn, and then, dried over magnesium sulfate. After the resultant solution was evaporated, the residue was distilled in vacuo to give ethyl 2-(1-acetoxyethyl)acrylate (41.44 g) as a colorless oil.

1. customquenched with water (200 ml)
2. customThe aqueous layer was separated
3. extractionextracted twice with dichloromethane
4. washThe combined organic layers were washed with 1N hydrochloric acid, saturated aqueous sodium hydrogen carbonate water
5. dry with materialan aqueous sodium chloride in turn, and then, dried over magnesium sulfate
6. customAfter the resultant solution was evaporated
7. distillationthe residue was distilled in vacuo