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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225566Generated: October 27, 2026

2-Iodothiazole → 5-Thiazol-2-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/225566

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-IodothiazoleHCID 10867563—
ReactantTert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)isoindoline-2-carboxylateHCID 16102684—
Product5-Thiazol-2-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl esterHCID 57753489—

Reaction Steps

Prepared in analogy to Example A23(b) from 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and 2-Iodo-thiazole (CAS: 3034-54-6). Yellow oil. MS (m/e): 303.1 ([M+H]+, 100%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557114B2
Source datasetuspto-grants-2009_07
ORD IDord-701a6050c9aa40de9b772921ac123a92
Source noteuspto-grants-2009_07