HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pentane → 4,4,4-Trifluorobutanoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pentane | HCID 8003 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4,4,4-Trifluorobutanoic acid | HCID 2777085 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4,4,4-Trifluorobutanoyl chloride | HCID 15104474 | 76% |
Reaction Steps
To a mixture of 131 g of 4,4,4-trifluorobutyric acid and 1 liter of pentane, 101 ml of oxalyl chloride and 0.1 ml of dimethylformamide were added, and the mixture was heated at reflux for 3 hours. The reaction solution was distilled at normal pressure to give 112 g of 4,4,4-trifluorobutyryl chloride (b.p. 103° C., 760 mmHg) (yield: 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05653990 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-f1c5097eb2154ea2915cdad8c07f8cf1 |
| Source note | uspto-grants-1997_08 |