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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225588Generated: October 30, 2026

4,4-Difluoropiperidine hydrochloride → HCID 57753513, compound

https://huagongshe.com/reaction/225588

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4,4-Difluoropiperidine hydrochlorideHCID 2758351—
Reactanttert-Butyl 5-iodoisoindoline-2-carboxylateHCID 57753580—
ProductHCID 57753513HCID 57753513—

Reaction Steps

Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 4,4-difluoropiperidine hydrochloride. Yellow solid. MS (m/e): 339.1 ([M+H]+, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557114B2
Source datasetuspto-grants-2009_07
ORD IDord-ef3174525d0440d6b3205b0527f8bb08
Source noteuspto-grants-2009_07