HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-(5-Amino-6-chloro-2-propylthiopyrimidine-4-ylamino)-5-(hydroxymethyl)-cyclopentane-1,2-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Amino-5-(hydroxymethyl)cyclopentane-1,2-diol | HCID 276738 | — |
| Reactant | 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine | HCID 11436336 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 3-(5-Amino-6-chloro-2-propylthiopyrimidine-4-ylamino)-5-(hydroxymethyl)-cyclopentane-1,2-diol | HCID 19028692 | — |
Reaction Steps
The product of step iv) (4.6 g) was added to a solution of 3-amino-5-(hydroxymethyl)-cyclopentane-1,2-diol (1.41 g) in butan-1-ol (200 ml) containing triethylamine (10 ml) and the whole heated to reflux for 48 hours. Evaporation gave a dark residue which was chromatographed (SiO2, 10% ethanol/dichloromethane) to afford the sub-title compound (2.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05654285 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-4871f2a537e94655b876e156cfd75ce7 |
| Source note | uspto-grants-1997_08 |