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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225592Generated: October 30, 2026

Hydrochloric Acid → 5-Chloro-6-morpholin-4-yl-2,3-dihydro-1H-isoindole hydrochloride

https://huagongshe.com/reaction/225592

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant5-Chloro-6-morpholin-4-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl esterHCID 57753302—
Product5-Chloro-6-morpholin-4-yl-2,3-dihydro-1H-isoindole hydrochlorideHCID 68826495—

Reaction Steps

Prepared in analogy to Example A3(e) from 5-chloro-6-morpholin-4-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Off-white solid. MS (m/e): 241.4 ({37Cl}M+H+, 52%), 239.3 ({35Cl}M+H+, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557114B2
Source datasetuspto-grants-2009_07
ORD IDord-4d7c1115dfa54ef0ad90d522556da6f7
Source noteuspto-grants-2009_07