5-(p-Hydroxymethylphenyl)imidazo[1,5-a]pyridine → 5-(p-Formylphenyl)-imidazo[1,5-a]pyridine

Participants

Reaction Steps

A solution of 5-(p-hydroxymethylphenyl)imidazo[1,5-a]pyridine (0.52 g) in 10 ml of methylene chloride is refluxed with 5.2 g of activated manganese dioxide for 24 h. An additional 5.2 g of manganese dioxide is added and the reaction mixture is refluxed an additional 6 h, filtered, and the solvent is evaporated to yield 5-(p-formylphenyl)-imidazo[1,5-a]pyridine, m.p. 144°-146°.

Provenance & Evidence