4-Tributylstannyl-3,6-dihydro-2H-pyran → HCID 57753653, compound

HRID 225602Notes

Reaction equation

HRID 225602 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:18]([F:21])([F:20])[F:19])=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C([Sn](CCCC)(CCCC)[C:27]1[CH2:28][CH2:29][O:30][CH2:31][CH:32]=1)CCC>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:18]([F:21])([F:20])[F:19])=[C:13]([C:27]3[CH2:32][CH2:31][O:30][CH2:29][CH:28]=3)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 222522584-Tributylstannyl-3,6-dihydro-2H-pyranHCID 57753490HCID 57753490, compound

Product 1

HCID 57753653HCID 57753653, compound

Procedure

Prepared in analogy to Example A49(a) from 5-iodo-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example 35(d)) and tributyl-(3,6-dihydro-2H-pyran-4-yl)-stannane. Yellow solid. MS (m/e): 314.0 ([M+H−Me2C═CH2]+, 100%).

Sources & evidence

ORD record
ord-164ec99288294f14b8a2bec3578eede5
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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