HCID 178418361, compound → HCID 178469888, compound

Participants

Reaction Steps

A solution of 1-benzyloxycarbonyl-4-(4-ethoxycarbonylimidazol-2-yl)piperidine (0.82 g) in ethanol (20 mL) was hydrogenated over 10% palladium on carbon (0.10 g) at a hydrogen pressure of 3.45 bar for 1 hour. The mixture was filtered through diatomaceous earth and the filter cake was washed with ethanol. The filtrate was evaporated to leave the piperidine derivative as a white foam (0.510 g); NMR: 7.65 (s, 1), 4.18 (q, 2, J=7.1), 2.99 (broad d, 2, J=12.2 H), 2.75 (m, 1), 2.55 (m, 2), 1.80 (broad d, 2, J=12.6), 1.57 (m, 2), 1.25 (t, 3, J=7.1); MS: m/z=252(M+1+28).

Provenance & Evidence