HCID 54178539, compound → HCID 11333358, compound

Participants

Reaction Steps

A solution of (3R*,4R*)-1-benzyloxycarbonyl-3-hydroxy-4-phenylpiperidine (0.3 g) in methanol (30 mL) was treated with 10% palladium on carbon (0.03 g) and hydrogenated at atmospheric pressure for 2 hours. The reaction mixture was filtered through diatomaceous earth and evaporated to afford (3R*,4R*)-3-hydroxy-4-phenylpiperidine (0.2 g); MS: m/z=178(M+1); NMR: 1.44-1.58 (m, 2), 2.23-2.5 (m, 9), 4.36 (broad, 1), 7.13-7.29 (m, 5).

Provenance & Evidence