Methanol → HCID 9873305, compound

Participants

Reaction Steps

Using a procedure similar to that described in Example 1 (alternative preparation), except using 4-(2-methylsulfinylphenyl)piperidine and (S)-N-[2-(3,4-dichlorophenyl)-4-oxobutyl]-N-methyl-benzamide, the title compound was prepared. Chromatography with dichloromethane:methanol followed by conversion to the hydrochloride salt gave a white solid; mp 71°-144° C.; MS: 557; NMR (CD3OD): 1.9-2.3 (m, 6), 2.4 (s, 1), 2.7-2.8 (two s, 3), 2.9-3.4 (br, 6), 3.5-3.9 (m, 4), 7.0 (m, 4), 7.3-7.6 (m, 7), 7.5-7.6 (m, 2). Analysis for C30H34Cl2NO2S·1.0 HCl·1.0 H2O: Calculated: C, 60.45; H, 6.26; N, 4.70; Found: C, 60.43; H, 5.91; N, 4.63.

Provenance & Evidence