Thiomorpholine 1,1-dioxide → HCID 57753673, compound

HRID 225605Notes

Reaction equation

HRID 225605 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[S:18]1(=[O:25])(=[O:24])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:21]3[CH2:22][CH2:23][S:18](=[O:25])(=[O:24])[CH2:19][CH2:20]3)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 6484228Thiomorpholine 1,1-dioxideHCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 57753673HCID 57753673, compound

Procedure

Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and tetrahydro-2H-1,4-thiazine 1,1-dioxide. Brown solid. MS (m/e): 353.0 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-0f0addb2c38d4850868947d9380578db
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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