Methanol → HCID 67713107, compound

Participants

Reaction Steps

Using a procedure similar to that described in Example 1 (alternative preparation), except using 4-(4-methylthiophenyl)piperidine and (S)-N-[2-(3,4-dichlorophenyl)-4-oxobutyl]-N-methylbenzamide, the title compound was prepared. Chromatography with dichloromethane:methanol followed by conversion to the hydrochloride salt gave a white solid; mp 73-92(dec) °C.; MS: 541; NMR (CD3OD): 1.8-2.2 (m, 6), 2.4 (s, 1), 2.7 (s, 3), 2.6-3.2 (m, 6), 3.4-3.8 (m, 4), 6.9 (d, J=7, 1), 7.1-7.2 (m, 6), 7.3 (m, 5), 7.5(m, 1). Analysis for C30H34Cl2NO2S·1.0HCl·1.0 H2O: Calculated: C, 60.45; H, 6.26; N, 4.70; Found: C, 60.23; H, 5.85; N, 4.70.

Provenance & Evidence