Methanol → HCID 67713289, compound

Participants

Reaction Steps

Using a procedure similar to that described in Example 1 (alternative preparation), except using 4-(4-methylsulfinylphenyl)piperidine and (S)-N-[2-(3,4-dichlorophenyl)-4-oxobutyl]-N-methylbenzamide, the title compound was prepared. Chromatography with dichloromethane:methanol followed by conversion to the hydrochloride salt gave a white solid; mp 94°-125° C.; MS: 557; NMR (CD3OD): 1.8-2.3 (m, 6), 2.8 (s, 6), 2.8-3.3 (br, 6), 3.4-3.9 (m, 4), 7.9-7.7 (m, 12). Analysis for C30H34Cl2NO2S·1.0 HCl·1.5 H2O: Calculated: C, 58.02; H, 6.17; N, 4.51; Found: C, 57.74; H, 6.00; N, 5.01.

Provenance & Evidence