反应详情

Using a procedure similar to that described in Example 1 (alternative preparation), except using 4-(2-hydroxyphenyl)piperidine and (S)-N-[2-(3,4-dichlorophenyl)-4-oxobutyl]-N-methylbenzamide, the title compound was prepared. Chromatography, eluting with dichloromethane:methanol, followed by conversion to the hydrochloride salt gave a white solid; mp 205°-210° C.; MS: 511; NMR (CD3OD): 1.7-2.3 (m, 6), 2.7 (s, 1), 2.8-3.1 (m, 6), 3.2-3.8 (m, 5), 6.7-6.8 (m, 2), 7.0 (t, J=7, 3), 7.2 (br, 2), 7.4 (br, 2), 7.4 (br, 4), 7.5-7.7 (m, 2), 9.5 (s, 10), 10.5 (s, 1). Analysis for C29H32Cl2N2O2 ·1.0 HCl·0.75 H2O: Calculated: C, 62.04; H, 6.19; N, 4.99; Found: C, 62.24; H, 6.15; N, 5.08.

1. customthat described in Example 1 (alternative preparation)
2. washChromatography, eluting with dichloromethane
3. customgave a white solid