4-Phenylpiperidin-4-ol → HCID 57753235, compound

HRID 225609Notes

Reaction equation

HRID 225609 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH:18][C:19]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:22]3[CH2:23][CH2:24][C:19]([OH:18])([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH2:20][CH2:21]3)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 963874-Phenylpiperidin-4-olHCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 57753235HCID 57753235, compound

Procedure

Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 4-hydroxy-4-phenylpiperidine. Yellow solid. MS (m/e): 395.1 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-5e7bad08d7f247baa13f2e1541514e35
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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