HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2256133Generated: October 30, 2026
3-Bromoaniline → 7-Amino-4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidine
https://huagongshe.com/reaction/2256133
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromoaniline | HCID 11562 | — |
| Reactant | 7-Amino-4-methylthiopyrido[4,3-d]pyrimidine | HCID 10442562 | — |
| Product | 7-Amino-4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidine | HCID 382059 | — |
Reaction Steps
A mixture of 7-amino-4-methylthiopyrido[4,3-d]pyrimidine (167 mg, 0.87 mmol) (described in a previous experimental) and 3-bromoaniline (0.75 mL, 7.8 mmol) is stirred under N2 at 190° C. for 2.5 h, and the precipitate which appears on cooling is recrystallized from PriOH. 1H NMR (DMSO) δ 9.91 (1H, brs), 9.34 (1H, s), 8.45 (1H, s), 8.19 (1H, s), 7.84 (1H, d, J=8.0 Hz), 7.34 (1H, t, J=8.0 Hz), 7.29 (1H, d, J=8.2 Hz), 6.68 (2H, brs), 6.45 (1H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05654307 |
|---|
| Source dataset | uspto-grants-1997_08 |
|---|
| ORD ID | ord-c649cf1b4b084cc09503fc054c6cc835 |
|---|
| Source note | uspto-grants-1997_08 |
|---|
