3-Methoxyazetidine hydrochloride → 5-(3-Methoxy-azetidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl Ester

HRID 225617Notes

Reaction equation

HRID 225617 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:19][O:20][CH:21]1[CH2:24][NH:23][CH2:22]1>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:23]3[CH2:24][CH:21]([O:20][CH3:19])[CH2:22]3)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 222428583-Methoxyazetidine hydrochlorideHCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylate

Product 1

HCID 577533255-(3-Methoxy-azetidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl Ester

Procedure

Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 3-methoxy-azetidine hydrochloride. Orange oil. MS (m/e): 305.4 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-aaab1384be9848179ef2e0a91061fd89
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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