tert-Butyl 5-iodoisoindoline-2-carboxylate → HCID 57753646, compound

HRID 225619Notes

Reaction equation

HRID 225619 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](I)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].FC(F)(F)C(O)=O.[CH3:25][O:26][CH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N:30]3[CH2:31][CH2:32][CH:27]([O:26][CH3:25])[CH2:28][CH2:29]3)[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 57753580tert-Butyl 5-iodoisoindoline-2-carboxylateHCID 68438517HCID 68438517, compound

Product 1

HCID 57753646HCID 57753646, compound

Procedure

Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 4-methoxy-piperidine trifluoroacetate. Yellow oil. MS (m/e): 333.3 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-60102be09fcb4d07931a7f5feaf87247
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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