HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-(5-Methyl-1,3,4-thiadiazol-2-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1,3,4-Thiadiazole, 2-amino-5-methyl- | HCID 66949 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | N-(5-Methyl-1,3,4-thiadiazol-2-yl)acetamide | HCID 234612 | 89.1% |
Reaction Steps
To a mixture of toluene (20 ml) and triethylamine(2.63 g) was added 2-amino-5- methyl-1,3,4-thiadiazole (3.0 g) and acetic anhydride (3.2 g). The mixture was heated under reflux for 2.5 hours. After cooling, the precipitated solid was filtrated, washed with water and dried. The title compound(3.65 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05654322 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-ebb96d616fb34fe39469aa22852012e5 |
| Source note | uspto-grants-1997_08 |