反应详情

n-Propylthiourea (270 mg), 3-chloro-2-oxohexanoic acid ethyl ester (441 mg), and pyridine (0.28 ml) were added to ethanol (10 ml), and the solution was refluxed for 3.5 hours. The solvent was evaporated. The residue was extracted with chloroform (20 ml), and washed with dilute hydrochloric acid solution (10 ml). The organic layer was dried over anhydrous magnesium sulfate and evaporated. The residue was purified by column chromatography on silica gel (eluent:chloroform/methanol=100/1), 2-n-propylamino-5-n-propyl thiazole-4-carboxylic acid ethyl ester (400 mg) was obtained.

1. temperaturethe solution was refluxed for 3.5 hours
2. customThe solvent was evaporated
3. extractionThe residue was extracted with chloroform (20 ml)
4. washwashed with dilute hydrochloric acid solution (10 ml)
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
6. customevaporated
7. customThe residue was purified by column chromatography on silica gel (eluent:chloroform/methanol=100/1)