HRID2256203

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14797

Potassium hydroxide

HKO

HCID178437927

未命名化合物

PRODUCTS

产物

HCID178437928

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

To a solution of 0.1N potassium hydroxide ethanolic solution (400 ml) and ethanol (600 ml) was added 2-[[5-Ethyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1,3,4-thiadiazoline-2-yliden]aminocarbonyl]-1-cyclopentenecarboxylic acid (10 g), and the mixture was heated on water bath. After the mixture had been completely dissolved, the solvent was concentrated to 200 ml in vacuo. The precipitated crystals were filtrated, washed with ethanol, and then dried in vacuo. The title compound (11 g) was obtained.

WORKUP

后处理

temperaturethe mixture was heated on water bath
dissolutionAfter the mixture had been completely dissolved
concentrationthe solvent was concentrated to 200 ml in vacuo
filtrationThe precipitated crystals were filtrated
washwashed with ethanol
customdried in vacuo

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-757fe495b5bc40b48795ec929375be36
来源数据集: uspto-grants-1997_08
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05654322
来源说明: uspto-grants-1997_08

反应SMILES

[OH-].[K+:2].[CH2:3]([C:5]1[S:9][C:8](=[N:10][C:11]([C:13]2[CH2:17][CH2:16][CH2:15][C:14]=2[C:18]([OH:20])=[O:19])=[O:12])[N:7]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:38][N:37]=[N:36][N:35]=3)=[CH:24][CH:23]=2)[N:6]=1)[CH3:4]>C(O)C>[CH2:3]([C:5]1[S:9][C:8](=[N:10][C:11]([C:13]2[CH2:17][CH2:16][CH2:15][C:14]=2[C:18]([O-:20])=[O:19])=[O:12])[N:7]([CH2:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:35][N:36]=[N:37][N:38]=3)=[CH:26][CH:27]=2)[N:6]=1)[CH3:4].[K+:2].[K+:2].[CH2:3]([C:5]1[S:9][C:8](=[N:10][C:11]([C:13]2[CH2:17][CH2:16][CH2:15][C:14]=2[C:18]([O-:20])=[O:19])=[O:12])[N:7]([CH2:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:35][N:36]=[N:37][N:38]=3)=[CH:26][CH:27]=2)[N:6]=1)[CH3:4]