Potassium Hydroxide → HCID 178437928, compound

HRID 2256203Notes

Reaction equation

HRID 2256203 reaction equation
[OH-].[K+:2].[CH2:3]([C:5]1[S:9][C:8](=[N:10][C:11]([C:13]2[CH2:17][CH2:16][CH2:15][C:14]=2[C:18]([OH:20])=[O:19])=[O:12])[N:7]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:38][N:37]=[N:36][N:35]=3)=[CH:24][CH:23]=2)[N:6]=1)[CH3:4]>C(O)C>[CH2:3]([C:5]1[S:9][C:8](=[N:10][C:11]([C:13]2[CH2:17][CH2:16][CH2:15][C:14]=2[C:18]([O-:20])=[O:19])=[O:12])[N:7]([CH2:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:35][N:36]=[N:37][N:38]=3)=[CH:26][CH:27]=2)[N:6]=1)[CH3:4].[K+:2].[K+:2].[CH2:3]([C:5]1[S:9][C:8](=[N:10][C:11]([C:13]2[CH2:17][CH2:16][CH2:15][C:14]=2[C:18]([O-:20])=[O:19])=[O:12])[N:7]([CH2:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:35][N:36]=[N:37][N:38]=3)=[CH:26][CH:27]=2)[N:6]=1)[CH3:4]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178437927HCID 178437927, compound

Product 1

HCID 178437928HCID 178437928, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 0.1N potassium hydroxide ethanolic solution (400 ml) and ethanol (600 ml) was added 2-[[5-Ethyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1,3,4-thiadiazoline-2-yliden]aminocarbonyl]-1-cyclopentenecarboxylic acid (10 g), and the mixture was heated on water bath. After the mixture had been completely dissolved, the solvent was concentrated to 200 ml in vacuo. The precipitated crystals were filtrated, washed with ethanol, and then dried in vacuo. The title compound (11 g) was obtained.

Workup

  1. temperaturethe mixture was heated on water bath
  2. dissolutionAfter the mixture had been completely dissolved
  3. concentrationthe solvent was concentrated to 200 ml in vacuo
  4. filtrationThe precipitated crystals were filtrated
  5. washwashed with ethanol
  6. customdried in vacuo

Sources & evidence

ORD record
ord-757fe495b5bc40b48795ec929375be36
Source dataset
uspto-grants-1997_08
Patent number
US05654322

Reaction notes

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