1-([1,1'-biphenyl]-2-ylmethyl)-2-ethyl-4-methoxy-1H-indole → 2-ethyl-4-hydroxy-1-(2-phenyl-phenylmethyl)-1H-indole

Participants

Reaction Steps

By the method used in Example 1, Part D, 911 mg (2.6 mmol) of 1-([1,1'-biphenyl]-2-ylmethyl)-2-ethyl-4-methoxy-1H-indole was O-demethylated by treating it with 10 mL of 1M BBr3 /CH2Cl2. The crude produce was chromatographed on silica gel and eluted with 20% EtOAc/hexane to give 590 mg (69% yield) of 1-([1,1'-biphenyl]-2-ylmethyl)-2-ethyl-4-hydroxy-1H-indole as an oil.

Provenance & Evidence