反应详情

3-(3,4-Dichlorophenyl)glutaric acid (100 g) was treated with acetyl chloride (300 mL) and the resulting mixture heated at reflux for 5 hours. The cooled reaction mixture was then azeotroped with toluene and concentrated under reduced pressure. The residue was slurried with diethyl ether (250 mL) and filtered to afford the title compound (86 g).

1. temperaturethe resulting mixture heated
2. temperatureat reflux for 5 hours
3. customThe cooled reaction mixture
4. customwas then azeotroped with toluene
5. concentrationconcentrated under reduced pressure
6. filtrationfiltered