Ethanol → HCID 19029343, compound

Participants

Reaction Conditions

Reaction Steps

Diethyl-3,4-difluorobenzal-bis-acetoacetate (11 g) in ethanol (150 mL) was treated with 50% NaOH (150 mL) and heated at reflux for 4 hours. Approximately 100 mL of solvent was removed by distillation. The remaining solution was cooled to 0° C. and sufficient HCl was added dropwise to adjust the pH to 1. The resulting solution was extracted with EtOAc (3×300 mL) and the combined extracts dried over MgSO4, filtered and concentrated under reduced pressure to give the title compound as a white solid (7.4 g).

Provenance & Evidence