N-Methylaniline → HCID 70196436, compound

Participants

Reaction Conditions

Reaction Steps

3-Phenylglutaric anhydride (8.0 g) in CH2Cl2 (100 mL) at 0° C. was treated sequentially with N-methylaniline (5.63 g), triethylamine (5.32 g) and N,N-dimethylaminopyridine (1.0 g). The mixture was stirred at 0° C. for two hours then allowed to warm to room temperature and stirred for 12 hours. The reaction mixture was washed with 1N HCl (2×50 mL) and water (100 mL). The organic layers were dried over MgSO4, filtered and concentrated to afford the title compound (11.5 g).

Provenance & Evidence