Triethylamine → HCID 70195521, compound

Participants

Reaction Conditions

Reaction Steps

3-Phenylglutaric anhydride (2.0 g) in CH2Cl2 (25 mL) at 0° C. was treated sequentially with 4-chloro-N-methylaniline (1.86 g), triethylamine (1.33 g) and N,N-dimethylaminopyridine (trace). The mixture was stirred at 0° C. for two hours then allowed to warm to room temperature and stirred for 12 hours. The reaction mixture was washed with 1N HCl (2×50 mL) and water (100 mL). The organic layers were dried over MgSO4, filtered and concentrated to afford the title compound (2.7 g).

Provenance & Evidence