Ethyl Acetate → HCID 19029356, compound

Participants

Reaction Conditions

Reaction Steps

N-(4-Chlorophenyl)-beta-(2-methanesulfonyloxyethyl)-N-methyl-benzenepropanamide (2.0 g) in DMF (10 mL) was treated with 4-acetylamino-4-phenylpiperidine hydrochlorode (3.21 g) and ethyl-N,N-diisopropylamine (2.48 g) and the mixture heated at 80° C. for 2 hours. The cooled reaction mixture was diluted the EtOAc (50 mL) and water (50 mL) and the aqueous phase removed. The aqueous layer was extracted with EtOAc (2×50 mL) and the combined organic extracts, washed with water (50 mL), dried over MgSO4, filtered and concentrated under reduced pressure to give an oil. Silica gel chromatography eluting with 10% MeOH:CHaCl2 gave the title compound (0.29 g). Mass spectrum (FAB): 518.3.

Provenance & Evidence