Triethylamine → HCID 19029363, compound

Participants

Reaction Steps

3,4-Dichloro-beta-(2-hydroxyethyl)-N-methyl-N-(4-chlorophenyl)-benzenepropanamide (3.6 g) in CH2Cl2 (100 mL) was cooled to -5° to -10° C. and treated sequentially with Et3N (1.62 mL), and methanesulfonyl chloride (0.9 mL). After two hours the reaction mixture was washed with water (100 mL), brine (100 mL) and the organic layer separated, dried over MgSO4, filtered and concentrated under reduced pressure to give the title compound (4.3 g).

Provenance & Evidence