2-Methoxyaniline → HCID 19029312, compound

Participants

Reaction Conditions

Reaction Steps

3-(3,4-Dichlorophenyl)glutaric anhydride (10 g, Example 1, Step C) in CH2Cl2 (150 mL) at 0° C. was treated sequentially with o-anisidine (6 mL), triethylamine (6.7 mL) and N,N-dimethylaminopyridine (440 mg). The mixture was stirred at 0° C. for two hours then allowed to warm to room temperature and stirred for 12 hours. The reaction mixture was diluted with CH2Cl2 (500 mL) and washed with 1N HCl (1×200 mL) and water (1×200 mL). The organic layers were dried over MgSO4, filtered and concentrated to afford the title compound (14 g).

Provenance & Evidence