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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225632Generated: October 29, 2026

HCID 57753365, compound → 4-(2,3-Dihydro-1H-isoindol-5-yl)-tetrahydro-pyran-4-ol

https://huagongshe.com/reaction/225632

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 57753365HCID 57753365—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
Product4-(2,3-Dihydro-1H-isoindol-5-yl)-tetrahydro-pyran-4-olHCID 57753680100%

Reaction Steps

To a stirred solution 0.39 mmol 4-(2-benzyl-2,3-dihydro-1H-isoindol-5-yl)-tetrahydro-pyran-4-ol in 20 ml methanol was added 40 mg 10% palladium on charcoal and the mixture was stirred under an atmosphere of hydrogen for 3 h. The reaction mixture was then filtered and the filtrate was concentrated in vacuo to yield the title compound as a yellow solid (100% yield). MS (m/e): 220.3 ([M+H]+, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557114B2
Source datasetuspto-grants-2009_07
ORD IDord-339e995f353440878f69c6f08c4012cd
Source noteuspto-grants-2009_07