Water → HCID 19028730, compound

Participants

Reaction Steps

To a solution of ethyl 3-cyano-3,3-diphenylpropionate (reference compound 2-1) (1.2 g) in tetrahydrofuran (30 ml) was added lithium aluminum hydride (0.44 g) portionwise with ice-cooling and stirring. After completion of dropwise addition, the mixture was heated and stirred at 60° C. for 3 hours. The reaction mixture was then cooled with ice again, and water (1 ml), 15% aqueous sodium hydroxide solution (3 ml) and water (1 ml) were added in the order mentioned. The resulting precipitate was filtered off and the filtrate was extracted using ethyl acetate and saturated aqueous sodium hydrogen carbonate solution. The organic layer was separated, washed with water, dried over anhydrous sodium sulfate, and concentrated to dryness. The residue was washed with ethyl acetate to provide the title compound (0.82 g) as colorless powder.

Provenance & Evidence