Acetyl chloride → HCID 19029773, compound

HRID 2256348Notes

Reaction equation

[OH:1][C:2]1[CH:17]=[C:16]([O:18][CH2:19][C:20]([C:22]2[CH:31]=[CH:30][C:29]3[C:28]([CH3:33])([CH3:32])[CH2:27][CH2:26][C:25]([CH3:35])([CH3:34])[C:24]=3[CH:23]=2)=[O:21])[CH:15]=[CH:14][C:3]=1[C:4]([O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5].[C:36](Cl)(=[O:38])[CH3:37]>>[C:36]([O:1][C:2]1[CH:17]=[C:16]([O:18][CH2:19][C:20]([C:22]2[CH:31]=[CH:30][C:29]3[C:28]([CH3:33])([CH3:32])[CH2:27][CH2:26][C:25]([CH3:35])([CH3:34])[C:24]=3[CH:23]=2)=[O:21])[CH:15]=[CH:14][C:3]=1[C:4]([O:6][CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:5])(=[O:38])[CH3:37]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 19029755HCID 19029755, compound

Product 1

HCID 19029773HCID 19029773, compoundYield 80%

Procedure

By reaction of 2.36 g (5 mmol) of benzyl 2-hydroxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthoylmethoxy)benzoate and 360 μl (5 mmol) of acetyl chloride in a manner analogous to Example 4(b), 2 g (80%) of the expected product which melts at 137°-138° C. are collected.

Sources & evidence

ORD record: ord-34fb44d677d84870afc68edbb1f73f38
Source dataset: uspto-grants-1997_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05654331

Reaction notes

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