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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225635Generated: October 29, 2026

Trifluoroacetic acid → 5-Methyl-6-(tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole trifluoro-acetate

https://huagongshe.com/reaction/225635

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant5-Methyl-6-(tetrahydro-pyran-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl esterHCID 57753472—
Product5-Methyl-6-(tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole trifluoro-acetateHCID 68824422—

Reaction Steps

Prepared in analogy to Example A2(c) from 5-methyl-6-(tetrahydro-pyran-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Yellow oil. MS (m/e): 218.4 ([M+H]+, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557114B2
Source datasetuspto-grants-2009_07
ORD IDord-374f9d3c18764aaf83fe7ae11eaf57da
Source noteuspto-grants-2009_07