Bromine → HCID 19029757, compound

HRID 2256351Notes

Reaction equation

HRID 2256351 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[S:10][CH2:9][CH2:8][C:7]2([CH3:15])[CH3:14])(=[O:3])[CH3:2].[Br:16]Br>>[Br:16][CH2:2][C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[S:10][CH2:9][CH2:8][C:7]2([CH3:15])[CH3:14])=[O:3]

Participants

3

Reactant 2

HCID 24408BromineHCID 117083551-(4,4-Dimethylthiochroman-6-yl)ethanone

Product 1

HCID 19029757HCID 19029757, compound

Procedure

In a manner analogous to Example 1(b), the synthesis is carried out starting from 1 g (4.42 mmol) of 6-acetyl-4,4-dimethylthiochroman and 700 mg (4.42 mmol) of bromine. After treatment and purification by chromatography on a silica column, eluting with a mixture of dichloromethane/hexane (40:60), 700 mg (53%) of expected bromo derivative are obtained in the form of a chestnut-brown oil.

Workup

  1. customAfter treatment and purification by chromatography on a silica column
  2. washeluting with a mixture of dichloromethane/hexane (40:60), 700 mg (53%) of expected bromo derivative
  3. customare obtained in the form of a chestnut-brown oil

Sources & evidence

ORD record
ord-9f90145781f1475eab84f43e592034ec
Source dataset
uspto-grants-1997_08
Patent number
US05654331

Reaction notes

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