Ethyl 5-(1-tritylimidazol-4-yl)-1-pent-2-enoate → 1H-Imidazole-4-pentanoic acid, 1-(triphenylmethyl)-, ethyl ester

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Reaction Steps

A solution of 9.20 g of ethyl 5-(1-tritylimidazol-4-yl)-1-pent-2-enoate in 460 ml of anhydrous ethanol is hydrogenated with 1.88 g of 10% palladium on charcoal at atmospheric pressure for 20 min. The catalyst is removed by filtration through celite. Evaporation provides a solid which is recrystallised from hexane to yield 8.64 g of ethyl 5-(1-tritylimidazol-4-yl)-1-pentanoate, m.p. 84°-86°.

Provenance & Evidence