3-Oxotetrahydrofuran → 3-(2-Benzyl-2,3-Dihydro-1H-isoindol-5-yl)-tetrahydro-furan-3-ol

HRID 225640Notes

Reaction equation

HRID 225640 reaction equation
[CH2:1]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13](Br)[CH:14]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:18]1[CH2:22][CH2:21][C:20](=[O:23])[CH2:19]1>>[CH2:1]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:20]3([OH:23])[CH2:21][CH2:22][O:18][CH2:19]3)[CH:14]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 5293923-OxotetrahydrofuranHCID 534165502-Benzyl-5-bromoisoindoline

Product 1

HCID 577533893-(2-Benzyl-2,3-Dihydro-1H-isoindol-5-yl)-tetrahydro-furan-3-ol

Procedure

Prepared in analogy to Example A62(b) from 2-benzyl-5-bromo-2,3-dihydro-1H-isoindole (Example A62(a)) and tetrahydrofuran-3-one. Brown oil. MS (m/e): 296.4 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-6eb42abbc303403b8d96a2d3fc7df56c
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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