Carbamate → HCID 9974494, compound

Participants

Reaction Steps

Following the general procedure of PREPARATION 3 and making non-critical variations 4-(4-pyridyl)-3,5-difluoroaniline (PREPARATION 8, 236 mg, 1.15 mmol) is converted to the carbamate derivative. The crude product is purified by silica gel chromatography (100 g of SG, eluted with a 3-5% acetonitrile/chloroform gradient), the title compound is recovered as a solid, mp 185°-186°; FTIR (neat) cm-1 1743, 1642, 1605, 1254, 1072; HRMS calc'd for C19H14F2N2O2 =340.1023, found=340.1029; MS (EI, m/z) 340, 232, 108, 91, 79, 43; NMR (CDCl3) δ 8.67, 7.43-7.38, 7.15, 5.23.

Provenance & Evidence