HuagongsheHuagongshe Chemistry Print Report · For research reference only
cis-2,6-dimethyloxan-4-one → rel-(2R,6S)-4-[2,3-Dihydro-2-(phenylmethyl)-1H-isoindol-5-yl]tetrahydro-2,6-dimethyl-2H-pyran-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | cis-2,6-dimethyloxan-4-one | HCID 10441716 | — |
| Reactant | 2-Benzyl-5-bromoisoindoline | HCID 53416550 | — |
| Product | rel-(2R,6S)-4-[2,3-Dihydro-2-(phenylmethyl)-1H-isoindol-5-yl]tetrahydro-2,6-dimethyl-2H-pyran-4-ol | HCID 57753466 | — |
Reaction Steps
Prepared in analogy to Example A62(b) from 2-benzyl-5-bromo-2,3-dihydro-1H-isoindole (Example A62(a)) and (2R,6S)-2,6-dimethyl-tetrahydro-pyran-4-one. Brown solid. MS (m/e): 338.4 ([M+H]+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557114B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-31903a586e1a428ab283b05e17606acc |
| Source note | uspto-grants-2009_07 |