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HRID2256734

反应详情

EQUATION

反应方程式

HRID 2256734 的结构方程式

REACTANTS

反应物

2
结构：NCCN1CCC(O)CC1
HCID2756425

1-(2-aminoethyl)piperidin-4-ol

C7H16N2O

结构：COCCCOc1cc(C[C@@H](C[C@H](NC(=O)OC(C)(C)C)C2C[C@@H](C)C(=O)O2)C(C)C)ccc1OC
HCID22865732

未命名化合物

PRODUCTS

生成物

1
结构：COCCCOc1cc(C[C@@H](C[C@H](NC(=O)OC(C)(C)C)[C@@H](O)C[C@@H](C)C(=O)NCCN2CCC(O)CC2)C(C)C)ccc1OC
HCID54295399

未命名化合物

PROCEDURE

实验过程

102 mg of 2-{1(S)-tert-butoxycarbonylamino-3(S)-isopropyl-4-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-butyl}-4(R)-methyl-tetrahydrofuran-5-one (Example 105e) and 0.5 g of N-(2-aminoethyl)-4-hydroxypiperidine are stirred for 2 hours at 80° C. The reaction mixture is purified by means of FC (60 g of silica gel, dichloromethane/methanol=4:1). The title compound is obtained: Rf (dichloromethane/methanol=4:1)=0.16.

WORKUP

后处理

  1. customThe reaction mixture is purified by means of FC (60 g of silica gel, dichloromethane/methanol=4:1)