2-(2-Nitroimidazol-1-yl)acetic acid → N-(3-methyl-2-butenyl)-2-(2-nitro-1H-imidazol-1-yl)acetamide

Participants

Reaction Steps

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (8.6 g, 50 mmol) was dissolved in DMF (50 mL). Carbonyl diimidazole [CDI] (8.7 g, 60 mmol) was added to the solution in small portions. The reaction mixture was stirred under N2 for 15 min. 3,3-Dimethylallylamine hydrochloride was suspended in DMF (50 mL) and stirred with NaHCO3 (4.2 g, 50 mmol). This suspension was added to the CDI and 2-(2-nitro-1H-imidazol-1-yl)acetic acid in DMF solution. The mixture was stirred under N2 atmosphere at room temperature overnight. TLC (silica gel, 10% methanol-dichloromethane) showed one spot with Rf =0.5, indicating completion of the reaction. DMF was evaporated on a rotary evaporator and the residue was triturated with ice-water (125 mL) and filtered. The solid was washed with cold water (3×50 mL) and dried in vacuum to give a white solid.

Provenance & Evidence